Draft Genome Sequences of Yersinia pestis Isolates from Natural Foci of Endemic Plague in China

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Complete genome sequences of Yersinia pestis from natural foci in China.

Yersinia pestis, the causative agent of plague, is a deadly bacterium that affects humans. Strain D106004 was isolated from a new plague focus in Yulong County, China, in 2006. To gain insights into the epidemic origin, we have sequenced the genomes of D106004 and strains Z176003 and D182038, isolated from neighboring regions.

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We deciphered the genome of Yersinia pestis strain 2501, isolated from the Junggar Basin, a newly discovered great gerbil plague focus in Xinjiang, China. The total length of assembly was 4,597,322 bp, and 4,265 coding sequences were predicted within the genome. It is the first Y. pestis genome from this plague focus.

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Yersinia pestis is the aetiological agent of plague, a disease of humans that has potentially devastating consequences. Evidence indicates that Y. pestis evolved from Yersinia pseudotuberculosis, an enteric pathogen that normally causes a relatively mild disease. Although Y. pestis is considered to be an obligate pathogen, the lifestyle of this organism is surprisingly complex. The bacteria are...

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Different Region Analysis for Genotyping Yersinia pestis Isolates from China

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 2009

ISSN: 0021-9193

DOI: 10.1128/jb.01227-09